Isopropylphenidate

Isopropylphenidate – A Popular Research Chemical

Isopropylphenidate (IPPH) is a popular research chemical that belongs to the family of phenidate compounds. It is a structural analog of methylphenidate (MPH), which is a commonly prescribed medication for attention deficit hyperactivity disorder (ADHD). IPPH was first synthesized in 2014 and has gained popularity in the research community due to its similar effects to MPH but with fewer side effects.

Chemical Properties

Isopropylphenidate has the chemical formula C16H23NO2 and a molar mass of 261.36 g/mol. It has a melting point of 98-100°C and a boiling point of 332.6°C at 760 mmHg. IPPH is a white crystalline powder that is soluble in organic solvents such as ethanol and chloroform.

Pharmacology

Isopropylphenidate acts as a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor, similar to methylphenidate. It increases the concentration of dopamine and norepinephrine in the brain, leading to increased focus, attention, and alertness. IPPH has a shorter duration of action compared to MPH, lasting for about 3-4 hours. It has a lower potential for abuse and dependence compared to MPH.

Uses

Isopropylphenidate is primarily used for research purposes, especially in the fields of neuroscience and pharmacology. It is often used as a substitute for methylphenidate in preclinical studies due to its similar effects. IPPH has also been used in forensic toxicology as a reference standard for drug testing.

Side Effects

The side effects of isopropylphenidate are similar to those of methylphenidate and include insomnia, decreased appetite, and anxiety. However, IPPH is generally considered to have fewer side effects than MPH due to its shorter duration of action and lower potency.

Legal Status

Isopropylphenidate is a controlled substance in some countries, including the United Kingdom and Sweden, where it is classified as a Class B drug. In the United States, it is not currently listed as a controlled substance, but it may be considered an analog of methylphenidate under the Federal Analog Act.

Conclusion

Isopropylphenidate is a popular research chemical that has gained attention in the scientific community due to its similar effects to methylphenidate but with fewer side effects. Its pharmacological properties and chemical structure make it a useful tool in preclinical studies, especially in the fields of neuroscience and pharmacology. While it is a controlled substance in some countries, it is not currently listed as a controlled substance in the United States.