2-Methyl-MAF

Introduction

2-Methyl-MAF, also known as 2-Methyl Methoxyacetylfentanyl, is a synthetic opioid analgesic that is structurally similar to other fentanyl analogs. It has become popular among drug users due to its potent analgesic effects and high affinity for the mu-opioid receptor.

Chemical Properties

2-Methyl-MAF has a molecular formula of C24H31NO3 and a molecular weight of 385.51 g/mol. Its chemical structure features a methyl group attached to the nitrogen atom of the fentanyl core, as well as a methoxyacetyl group attached to the para position of the phenyl ring. It has a melting point of 91-92°C and a boiling point of 615.5±45.0°C at 760 mmHg.

Synthesis

2-Methyl-MAF is typically synthesized through the acetylation of fentanyl, which involves the reaction of fentanyl with acetic anhydride in the presence of a catalyst such as pyridine or triethylamine. The resulting product is then methylated using methyl iodide and a base such as potassium carbonate or sodium hydroxide.

Pharmacology

2-Methyl-MAF exerts its pharmacological effects by binding to the mu-opioid receptor in the brain, spinal cord, and gastrointestinal tract. This results in a potent analgesic effect that is several times more potent than morphine. However, due to its high potency, it also carries a high risk of overdose and respiratory depression.

Uses

2-Methyl-MAF is not approved for any medical use, and is instead used recreationally as a potent analgesic and euphoriant. Due to its high potency and risk of overdose, it is considered a highly dangerous substance and is classified as a Schedule I controlled substance in many countries.

Side Effects

The use of 2-Methyl-MAF can result in a range of side effects, including nausea, vomiting, constipation, respiratory depression, and even death. It is also highly addictive and can lead to the development of tolerance and dependence with chronic use.

Conclusion

In conclusion, 2-Methyl-MAF is a highly potent synthetic opioid analgesic that is structurally similar to other fentanyl analogs. It is not approved for any medical use and is instead used recreationally as a potent analgesic and euphoriant. However, its high potency and risk of overdose make it a highly dangerous substance that should be avoided at all costs.