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BK-2C-B is a synthetic psychoactive substance that is structurally similar to mescaline, a natural hallucinogen found in various cacti. This compound is a phenethylamine derivative, and it is known for its psychedelic effects, such as altered thinking, perception, and mood. BK-2C-B has been marketed as a research chemical and is usually consumed orally or nasally. In this article, we will explore the various aspects of BK-2C-B, including its history, pharmacology, effects, and risks.

History of BK-2C-B
BK-2C-B was first synthesized by a team of researchers led by David E. Nichols in 1993. Nichols is a renowned chemist who has contributed significantly to the field of psychedelic drug research. BK-2C-B was initially investigated for its potential therapeutic uses, but it was later marketed as a recreational drug due to its psychedelic effects. The compound has been sold online as a research chemical since the early 2010s, and its use has been associated with numerous adverse effects and fatalities.

Pharmacology of BK-2C-B
BK-2C-B acts as a serotonin receptor agonist, primarily targeting the 5-HT2A receptor subtype. It also has affinity for other serotonin receptors, such as 5-HT2B and 5-HT2C. The activation of these receptors by BK-2C-B leads to the release of various neurotransmitters, such as dopamine and norepinephrine, which are responsible for its psychoactive effects. The exact mechanism of action of BK-2C-B is not fully understood, but it is believed to involve the modulation of various signaling pathways in the brain.

Effects of BK-2C-B
The effects of BK-2C-B are similar to those of other psychedelic substances. The onset of the effects is usually within 30 to 60 minutes of ingestion, and they can last for up to 8 hours. The most commonly reported effects include altered perception of time, space, and reality, enhanced mood, and increased empathy. Some users have also reported experiencing synesthesia, which is a condition where one sense triggers another. For example, a user may see colors when they hear music. The intensity of the effects of BK-2C-B can vary depending on the dose, route of administration, and individual factors such as age, weight, and tolerance.

Risks of BK-2C-B
The use of BK-2C-B has been associated with various adverse effects and fatalities. These risks include:

Overdose: BK-2C-B is a potent substance, and its effects can be unpredictable. Taking too much of the substance can lead to an overdose, which can cause serious harm or death.

Psychological effects: The use of BK-2C-B can cause anxiety, paranoia, and hallucinations. These effects can be particularly dangerous for individuals with pre-existing mental health conditions.

Physical effects: BK-2C-B can cause physical effects such as increased heart rate, high blood pressure, and hyperthermia. These effects can be particularly dangerous for individuals with pre-existing medical conditions.

Legal status: The sale and possession of BK-2C-B are illegal in many countries, including the United States and the United Kingdom. The substance is classified as a Schedule I controlled substance in the US, meaning that it has a high potential for abuse and no accepted medical use.

In conclusion, BK-2C-B is a synthetic psychoactive substance that is marketed as a research chemical.


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