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3-HO-PCE is a synthetic dissociative substance that belongs to the arylcyclohexylamine class of chemicals. It is also known as 3-Hydroxyeticyclidine and is closely related to the well-known dissociative anesthetic drug, PCP. 3-HO-PCE is a relatively new research chemical that has gained popularity among the scientific community due to its unique chemical structure and properties.

Chemical Properties

The chemical formula of 3-HO-PCE is C14H20ClNO, and its molecular weight is 251.77 g/mol. It has a melting point of 201-202°C and a boiling point of 369.9°C at 760 mmHg. The compound is typically synthesized in a laboratory setting using various organic synthesis techniques.


3-HO-PCE acts as an NMDA receptor antagonist, similar to other dissociative drugs like ketamine and PCP. It is known to cause dissociative and hallucinogenic effects, leading to altered states of consciousness and a loss of sense of self. The substance has been found to have a longer duration of action and a slower onset than other dissociative drugs, which may make it more appealing to certain researchers.


The effects of 3-HO-PCE are dose-dependent and can vary widely based on the individual and the dose consumed. At lower doses, users may experience mild dissociative effects, such as changes in perception, euphoria, and a sense of detachment from reality. Higher doses can lead to more intense effects, including hallucinations, disorientation, and an altered sense of time and space.

Side Effects and Risks

As with any research chemical, there are risks associated with the use of 3-HO-PCE. Some potential side effects of the substance may include nausea, vomiting, confusion, and anxiety. There is also a risk of addiction and dependence with prolonged use. Additionally, the long-term effects of 3-HO-PCE use are not yet fully understood, and further research is needed to fully evaluate the safety of the substance.

Legal Status

3-HO-PCE is not currently regulated in many countries, including the United States and the United Kingdom. However, it is important to note that the legal status of research chemicals can change rapidly, and it is always important to stay up to date on the latest regulations and laws in your area before engaging in any research involving these substances.


3-HO-PCE is a relatively new research chemical that has gained attention in recent years due to its unique pharmacological profile and potential therapeutic uses. While the long-term effects and safety of the substance are not yet fully understood, it has shown promise in certain research applications. As with any research chemical, it is important to use caution and carefully evaluate the risks and benefits before engaging in any research involving 3-HO-PCE.


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