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Pentedrone: A Brief Introduction

Pentedrone, also known as α-methylamino-valerophenone, is a designer drug belonging to the cathinone class of drugs. It is a stimulant and shares structural similarities with other cathinones such as MDPV and methylone. Pentedrone is a synthetic substance and has been marketed as a legal alternative to other stimulants like cocaine and amphetamines.

The Chemistry of Pentedrone

Pentedrone has a molecular formula of C12H17NO and a molar mass of 191.27 g/mol. It has a chiral center and can exist in two enantiomeric forms, (R)-(-)-pentedrone and (S)-(+)-pentedrone. Pentedrone is a white crystalline powder and is soluble in water, ethanol, and methanol. It has a melting point of 122-123 °C.

Synthesis of Pentedrone

Pentedrone is a synthetic substance and can be synthesized using various methods. One of the most commonly used methods involves the reaction of 2-Bromovalerophenone with methylamine.

Effects of Pentedrone

Pentedrone is a psychoactive substance and can produce stimulating effects similar to other stimulants. It can increase the levels of neurotransmitters such as dopamine, serotonin, and norepinephrine in the brain. Pentedrone can cause euphoria, increased energy levels, increased heart rate, increased blood pressure, and reduced appetite. It can also cause anxiety, agitation, and paranoia, especially at high doses.

Medical Uses of Pentedrone

Pentedrone has no approved medical uses and is not used in any clinical settings.

Legal Status of Pentedrone

Pentedrone is a controlled substance in several countries, including Sweden, Australia, and the United Kingdom. In the United States, pentedrone is not currently scheduled under the Controlled Substances Act but is considered a controlled substance analog and may be prosecuted under the Federal Analog Act.


In conclusion, pentedrone is a synthetic cathinone and a psychoactive substance with stimulating effects. It is a controlled substance in several countries and has no approved medical uses. The use of pentedrone can cause several adverse effects, and its consumption must be avoided. It is important to understand the potential risks associated with the use of pentedrone and other similar substances.


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