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3-MeO-PCP is a dissociative anesthetic drug that belongs to the arylcyclohexylamine class. It is also known as 3-Methoxyphencyclidine and has a chemical structure similar to phencyclidine (PCP). The drug was first synthesized in 1979 by a team of researchers at the Parke-Davis company.

Chemical Properties

3-MeO-PCP has a molecular formula of C18H27NO and a molar mass of 273.42 g/mol. It has a white crystalline powder appearance and is soluble in organic solvents such as ethanol and acetone. The drug is usually taken orally, although it can also be snorted or injected intravenously.

Mechanism of Action

3-MeO-PCP works by blocking the NMDA receptors in the brain, which are responsible for transmitting signals between neurons. This results in a dissociative state, where the user feels detached from their surroundings and experiences an altered sense of reality. The drug also affects the dopamine and serotonin receptors, leading to feelings of euphoria and stimulation.


The effects of 3-MeO-PCP can last for up to 8 hours, depending on the dosage and method of administration. Users typically report a variety of physical and psychological effects, including:

Physical effects:

  • Decreased pain perception
  • Increased heart rate and blood pressure
  • Numbness and tingling sensations
  • Loss of coordination and balance

Psychological effects:

  • Euphoria and intense pleasure
  • Distorted sense of time and space
  • Altered perception of reality
  • Feelings of detachment and disconnection

Side Effects

As with any drug, 3-MeO-PCP can have negative side effects, especially when taken in large doses. Some common side effects include:

  • Nausea and vomiting
  • Agitation and anxiety
  • Hallucinations and delusions
  • Psychotic episodes
  • Seizures and convulsions
  • Cardiac arrest

Legal Status

3-MeO-PCP is classified as a Schedule I drug in the United States, which means it has a high potential for abuse and no currently accepted medical use. It is also illegal in many other countries around the world.


3-MeO-PCP is a dissociative anesthetic drug that can have profound effects on the mind and body. While it may be used for medical purposes in the future, its high potential for abuse and dangerous side effects make it a drug of concern. As with any drug, it should only be taken under the supervision of a qualified medical professional.


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