MDAI

Introduction

MDAI, also known as 5,6-Methylenedioxy-2-aminoindane, is a psychoactive substance that belongs to the class of entactogens. It is structurally similar to MDMA (Ecstasy) but has a distinct chemical makeup. MDAI has been sold as a designer drug and is not approved for medical use.

Chemical Properties

MDAI has a molecular formula of C10H11NO2 and a molecular weight of 177.201 g/mol. It has a melting point of 144-145°C and a boiling point of 283°C. MDAI is soluble in ethanol, methanol, and chloroform, but is insoluble in water. It is usually sold as a white or off-white powder.

Mechanism of Action

MDAI is believed to act as a selective serotonin releasing agent (SSRA) and has been shown to increase serotonin levels in the brain. It is also thought to have some affinity for dopamine and norepinephrine receptors, but to a lesser extent than serotonin receptors.

Effects

MDAI is known for its empathogenic and entactogenic effects, which can include feelings of euphoria, love, and empathy. Users have reported increased sociability and a desire to connect with others. The effects of MDAI can last up to 8 hours.

Short-term effects

The short-term effects of MDAI can include:

• Euphoria
• Empathy
• Increase in sociability
• Increased heart rate and blood pressure
• Chills and sweating
• Dilated pupils
• Jaw clenching

Long-term effects

The long-term effects of MDAI are not well understood. However, research suggests that long-term use of serotonergic drugs can lead to serotonin depletion and neurotoxicity. There may also be a risk of addiction and other negative health consequences associated with frequent or high-dose use.

Legal Status

MDAI is a controlled substance in many countries, including the United States and the United Kingdom. It is illegal to possess, sell, or distribute MDAI for human consumption. However, it may be legal for research purposes or as an analytical standard.

Conclusion

MDAI is a psychoactive substance with empathogenic and entactogenic effects. It acts as a selective serotonin releasing agent and is structurally similar to MDMA. However, it is not approved for medical use and is illegal in many countries. The long-term effects of MDAI are not well understood, but there may be a risk of addiction and other negative health consequences associated with frequent or high-dose use.